Journal: Nature Communications
Article Title: Deep brain stimulation of symptom-specific networks in Parkinson’s disease
doi: 10.1038/s41467-024-48731-1
Figure Lengend Snippet: A DBS Today. A well-placed, standard omnidirectional Medtronic 3389 electrode is shown with a single stimulation volume that equally covers all symptom-specific tracts. B DBS in the future. A hypothetical future concept with a modern electrode (Boston Scientific Cartesia X electrode with 15 directional and one omnidirectional contact) is shown. With some devices, it is possible to steer multiple stimulation volumes toward individual tracts. In our example, one stimulation could target tremor streamlines (potentially with a high frequency of ~180 Hz). A second volume would focus on the axial/gait streamlines connecting to the PPN region (potentially with a low frequency of ~25 Hz). L = Lateral, A = Anterior, I = Inferior.
Article Snippet: These patients had been implanted with directional electrodes (Boston Scientific Vercise Cartesia) and for the directional levels with best clinical response, each segment had been tested in increasing 1 mA steps until a side effect occurred or until reaching 5 mA.
Techniques: